Mechanisms of action and therapeutic application of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2018 - cell.com
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-
related glycemic excursions through augmentation of insulin and inhibition of glucagon …

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

KL Mertens, A Kalsbeek, MR Soeters… - Frontiers in …, 2017 - frontiersin.org
Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Factors influencing gallstone formation: a review of the literature

H Sun, J Warren, J Yip, Y Ji, S Hao, W Han, Y Ding - Biomolecules, 2022 - mdpi.com
Gallstone disease is a common pathology of the digestive system with nearly a 10–20%
incidence rate among adults. The mainstay of treatment is cholecystectomy, which is …

Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study

JC Lai, AM Shui, A Duarte‐Rojo, DR Ganger… - Hepatology, 2022 - journals.lww.com
Conclusions Compared with nonfrail patients, frail LT recipients had a higher risk of post‐LT
death and greater post‐LT health care utilization, although overall post‐LT survival was …

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism

AM Martin, EW Sun, DJ Keating - Journal of Endocrinology, 2020 - joe.bioscientifica.com
The homoeostatic regulation of metabolism is highly complex and involves multiple inputs
from both the nervous and endocrine systems. The gut is the largest endocrine organ in our …

[HTML][HTML] Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits

BP Kok, A Galmozzi, NK Littlejohn, V Albert… - Molecular …, 2018 - Elsevier
Objectives Extracts of the hops plant have been shown to reduce weight and insulin
resistance in rodents and humans, but elucidation of the mechanisms responsible for these …

A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome.

ER Kim, JS Park, JH Kim, JY Oh, IJ Oh… - Hepatology …, 2021 - europepmc.org
A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and
microbiome. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC …

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice

PD Finn, D Rodriguez, J Kohler… - American Journal …, 2019 - journals.physiology.org
Takeda G protein-coupled receptor 5 (TGR5) agonists induce systemic release of glucagon-
like peptides (GLPs) from intestinal L cells, a potentially therapeutic action against metabolic …

Dynamics of the enterohepatic circulation of bile acids in healthy humans

F Stellaard, D Lütjohann - American Journal of Physiology …, 2021 - journals.physiology.org
Regulation of bile acid metabolism is normally discussed as the regulation of bile acid
synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool …

Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti‐tumor immunity

LM Sipe, M Chaib, AK Pingili, JF Pierre… - Immunological …, 2020 - Wiley Online Library
Bile acids (BAs) are known facilitators of nutrient absorption but recent paradigm shifts now
recognize BAs as signaling molecules regulating both innate and adaptive immunity. Bile …