For cancer screening to be successful, it should primarily detect cancers with lethal potential
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

The complicated interplay between cancer and the host immune system has been studied
for decades. New insights into the human immune system as well as the mechanisms by …

Solid tumors, beyond mere accumulation of cancer cells, form a complex ecosystem
consisting of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural …

Ionizing radiation is often regarded as an element of danger. But, danger responses on the
cellular and molecular level are often beneficial with regard to the induction of anti‐tumor …

The outcome of tumors results from genetic and epigenetic modifications of the transformed
cells and also from the interactions of the malignant cells with their tumor microenvironment …

Exercise improves functional capacity and patient-reported outcomes across a range of
cancer diagnoses. The mechanisms behind this protection have been largely unknown, but …

Despite remarkable recent achievements of immunotherapy strategies in cancer treatment,
clinical responses remain limited to subsets of patients. Predictive markers of disease …

Prostate cancer is the most commonly diagnosed cancer and the second leading cause of
cancer-related death among men in western countries. Androgen deprivation therapy (ADT) …