ROS and diseases: Role in metabolism and energy supply

S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …

Toxicity of mercury: Molecular evidence

L Yang, Y Zhang, F Wang, Z Luo, S Guo, U Strähle - Chemosphere, 2020 - Elsevier
Minamata disease in Japan and the large-scale poisoning by methylmercury (MeHg) in Iraq
caused wide public concerns about the risk emanating from mercury for human health …

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

M Farina, DS Avila, JBT Da Rocha… - Neurochemistry …, 2013 - Elsevier
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies

M Farina, JBT Rocha, M Aschner - Life sciences, 2011 - Elsevier
Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Environmental toxicity, oxidative stress and apoptosis: menage a trois

R Franco, R Sánchez-Olea, EM Reyes-Reyes… - … /Genetic Toxicology and …, 2009 - Elsevier
Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …

DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Oxidative stress in MeHg-induced neurotoxicity

M Farina, M Aschner, JBT Rocha - Toxicology and applied pharmacology, 2011 - Elsevier
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …

Methylmercury and brain development: A review of recent literature

AA Dos Santos, MA Hort, M Culbreth… - Journal of trace …, 2016 - Elsevier
Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in
humans. The central nervous system (CNS) is the primary target of toxicity, and is …

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

M Farina, M Aschner - Biochimica et Biophysica Acta (BBA)-General …, 2019 - Elsevier
Methylmercury (MeHg) is a toxic chemical compound naturally produced mainly in the
aquatic environment through the methylation of inorganic mercury catalyzed by aquatic …

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

AK Krug, R Kolde, JA Gaspar, E Rempel… - Archives of …, 2013 - Springer
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often
manifest themselves in functional deficits that are not necessarily based on cell death, but …