The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …