Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for~ 5%
of global disease burden. A minority of people with recreational alcohol use develop alcohol …

Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during
alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in …

We recently developed a rat model of incubation of methamphetamine craving after choice-
based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and …

Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-
seeking associated with several drugs of abuse and thus represents a promising …

Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We
recently used alcohol self-administration that is resistant to footshock punishment as a …

The central nucleus of the amygdala plays a significant role in alcohol use and other
affective disorders; however, the genetically-defined neuronal subtypes and projections that …

Abstract Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have
become a premier neuroscience research tool for enabling reversible manipulations of …

Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities
globally. Affective disturbances, including stress, depression, and anxiety, are highly …