Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin
complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing …

Inherited cardiomyopathies form a heterogenous group of disorders that affect the structure
and function of the heart. Defects in the genes encoding sarcomeric proteins are associated …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in
response to Ca 2+. TnC binding Ca 2+ initiates a cascade of protein–protein interactions …

Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …

Acto-myosin cross-bridge kinetics are important for beat-to-beat regulation of cardiac
contractility; however, physiological and pathophysiological mechanisms for regulation of …

Familial cardiomyopathy is an inherited disease that affects the structure and function of
heart muscle and has an extreme range of phenotypes. Among the millions of affected …

Familial dilated cardiomyopathy (DCM), clinically characterized by enlargement and
dysfunction of one or both ventricles of the heart, can be caused by variants in sarcomeric …

The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-
domain, causes generalised instability at multiple sites in the isolated protein. As a result …

Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been
associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect …