The global problem of antifungal resistance: prevalence, mechanisms, and management

DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

A Chowdhary, S Kathuria, J Xu, JF Meis - PLoS pathogens, 2013 - journals.plos.org
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global
leading cause of aspergillosis and causes one of the highest numbers of deaths among …

Fitness trade-offs restrict the evolution of resistance to amphotericin B

BM Vincent, AK Lancaster, R Scherz-Shouval… - PLoS …, 2013 - journals.plos.org
The evolution of drug resistance in microbial pathogens provides a paradigm for
investigating evolutionary dynamics with important consequences for human health …

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

A Rosenberg, IV Ene, M Bibi, S Zakin, ES Segal… - Nature …, 2018 - nature.com
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design

JD Smith, S Suresh, U Schlecht, M Wu, O Wagih… - Genome biology, 2016 - Springer
Background Genome-scale CRISPR interference (CRISPRi) has been used in human cell
lines; however, the features of effective guide RNAs (gRNAs) in different organisms have not …

Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development

M Bondaryk, W Kurzątkowski… - Advances in Dermatology …, 2013 - termedia.pl
Recent progress in medical sciences and therapy resulted in an increased number of
immunocompromised individuals. Candida albicans is the leading opportunistic fungal …

[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi

MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …

Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in Penicillium digitatum

Q OuYang, Y Liu, OR Oketch, M Zhang, X Shao, N Tao - Journal of Fungi, 2021 - mdpi.com
Ergosterol (ERG) is a potential target for the development of antifungal agents against
Penicillium digitatum, the pathogen of green mold in citrus fruits. This study examined the …