The global problem of antifungal resistance: prevalence, mechanisms, and management
DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …
outcome. Only a few classes of antifungal drugs are available, so the emergence of …
Antifungal therapy: new advances in the understanding and treatment of mycosis
L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
Emerging threats in antifungal-resistant fungal pathogens
D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
antifungal resistance. Resistance has been described for virtually all antifungal agents in …
Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global
leading cause of aspergillosis and causes one of the highest numbers of deaths among …
leading cause of aspergillosis and causes one of the highest numbers of deaths among …
Fitness trade-offs restrict the evolution of resistance to amphotericin B
BM Vincent, AK Lancaster, R Scherz-Shouval… - PLoS …, 2013 - journals.plos.org
The evolution of drug resistance in microbial pathogens provides a paradigm for
investigating evolutionary dynamics with important consequences for human health …
investigating evolutionary dynamics with important consequences for human health …
Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …
Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
Background Genome-scale CRISPR interference (CRISPRi) has been used in human cell
lines; however, the features of effective guide RNAs (gRNAs) in different organisms have not …
lines; however, the features of effective guide RNAs (gRNAs) in different organisms have not …
Antifungal agents commonly used in the superficial and mucosal candidiasis treatment: mode of action and resistance development
M Bondaryk, W Kurzątkowski… - Advances in Dermatology …, 2013 - termedia.pl
Recent progress in medical sciences and therapy resulted in an increased number of
immunocompromised individuals. Candida albicans is the leading opportunistic fungal …
immunocompromised individuals. Candida albicans is the leading opportunistic fungal …
[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi
MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …
increasing rate of fungal infections caused by strains that are resistant to commonly used …
Citronellal Exerts Its Antifungal Activity by Targeting Ergosterol Biosynthesis in Penicillium digitatum
Q OuYang, Y Liu, OR Oketch, M Zhang, X Shao, N Tao - Journal of Fungi, 2021 - mdpi.com
Ergosterol (ERG) is a potential target for the development of antifungal agents against
Penicillium digitatum, the pathogen of green mold in citrus fruits. This study examined the …
Penicillium digitatum, the pathogen of green mold in citrus fruits. This study examined the …