Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular
processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the …

Most of the newly discovered compounds showing promise for the treatment of TB, notably
multidrug-resistant TB, inhibit aspects of Mycobacterium tuberculosis cell envelope …

The development of next-generation antimalarials that are efficacious against the human
liver and asexual blood stages is recognized as one of the world's most pressing public …

Metabolism underpins the physiology and pathogenesis of Mycobacterium tuberculosis.
However, although experimental mycobacteriology has provided key insights into the …

In 1980 sulfamic acid and its N-substituted derivatives were reviewed in Chemical Reviews,
1 effectively updating an earlier 1940 review 2 also in Chemical Reviews. In 1991 the …

Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …

Drug metabolism is generally associated with liver enzymes. However, in the case of
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), Mtb-mediated …

Pseudomonas aeruginosa is an opportunistic pathogen that predominantly causes
nosocomial and community-acquired lung infections. As a member of ESKAPE pathogens …

A fundamental mechanism that all eukaryotic cells use to adapt to their environment is
dynamic protein modification with monosaccharide sugars. In humans, O-linked N …

Mycobacterium tuberculosis (Mtb) is the deadliest bacterial pathogen in the world. An
estimated one-third of humans harbor Mtb in a dormant state. These asymptomatic, latent …