The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …

CFTR chloride channels are encoded by the gene mutated in patients with cystic fibrosis.
These channels belong to the superfamily of ABC transporter ATPases. ATP-driven …

Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …

We present an overview of the architecture of ATP-binding cassette (ABC) transporters and
dissect the systems in core and accessory domains. The ABC transporter core is formed by …

Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Intrinsically disordered proteins play crucial roles in regulatory processes and often function
as protein interaction hubs. Here, we present a detailed characterization of a full-length …

The cystic fibrosis transmembrane conductance regulator (CFTR) architecture consists of
two membrane spanning domains (MSD1 and-2), two nucleotide binding domains (NBD1 …

Cystic fibrosis transmembrane conductance regulator (CFTR), involved in cystic fibrosis
(CF), is a chloride channel belonging to the ATP-binding cassette (ABC) superfamily. Using …

Mutations of the CFTR gene cause cystic fibrosis (CF), the most common recessive
monogenic disease worldwide. These mutations alter the synthesis, processing, function, or …