The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Cholera and the related Escherichia coli-associated diarrheal disease are important
problems confronting Third World nations and any area where water supplies can become …

A WIDE variety of membrane transformations important in intracellular transport are inhibited
by the fungal metabolite brefeldin A (refs 1–4), implying that the target for this drug is central …

ADP-ribosylation factor (ARF) 6 localizes to the plasma membrane (PM) in its GTP state and
to a tubulovesicular compartment in its GDP state in HeLa cells that express wild-type or …

Using three different trans dominant mutants of bovine ARF1 affecting GDP exchange or
GTP hydrolysis we demonstrate the central role of ARF1 in controlling vesicular traffic from …

Aberrant activation of EGFR due to overexpression or mutation is associated with poor
prognosis in many types of tumors. Here we show that blocking the sorting system that …

Adenosine diphosphate-ribosylation factor 6 (ARF6), ARF6 mutants, and ARF1 were
transiently expressed in Chinese hamster ovary cells, and the effects on receptor-mediated …

Activation of the phospholipase D (PLD) pathway is a widespread response when cells are
activated by agonists that bind receptors on the cell surface. A 16-kD cytosolic component …

The small GTP-binding protein, ADP-ribosylation factor (AM), has previously been shown to
mediate the binding to Golgi membranes of the coatomer of nonclathrin-coated (COP …

The ARF6 GTPase regulates a novel endosomal-plasma membrane recycling pathway and
influences cortical actin remodeling. Here we examined the relationship between ARF6 and …