The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumor microenvironment, and cancer immune evasion largely involves the …

Simple Summary CD73 and adenosine are garnering significant attention in lung cancer
research. CD73, an enzyme crucial for adenosine production, is found in various cells …

Background Advances in tumor immunotherapy have been developed for patients with
advanced recurrent or metastatic (R/M) HNSCC. However, the response of most HNSCC …

Nerve-cancer crosstalk resulting in either tumor neurogenesis or intratumoral
neurodegeneration is critically controlled by Schwann cells, the principal glial cells of the …

Background Multiple myeloma (MM) is a malignancy of plasma cells that arises from
premalignant Monoclonal Gammopathy of Undetermined Significance (MGUS) and often …

The cutting edge of cancer immunotherapy extends to ecto-5′-nucleotidase (CD73), a cell
membrane enzyme that targets the metabolism of extracellular adenosine. We herein …

Background Single agent anti-PD1 therapy has shown limited clinical benefit in
liposarcoma, but combination with anti-CTLA-4 demonstrated a higher response rate. 1-3 In …

Clinical and translation immunology research in EJI continues to grow (about a quarter of
our published content in 2020), and are among EJI's top read articles. GRAPH Dear readers …

Alternative splicing (AS) is an essential, but under-investigated component of T-cell function
during immune responses. Recent developments in RNA sequencing (RNA-seq) …