Chromatin hydrodynamics

R Bruinsma, AY Grosberg, Y Rabin, A Zidovska - Biophysical journal, 2014 - cell.com
Following recent observations of large scale correlated motion of chromatin inside the nuclei
of live differentiated cells, we present a hydrodynamic theory—the two-fluid model—in which …

Understanding the dynamics of rings in the melt in terms of the annealed tree model

J Smrek, AY Grosberg - Journal of Physics: Condensed Matter, 2015 - iopscience.iop.org
The dynamical properties of a long polymer ring in a melt of unknotted and unconcatenated
rings are calculated. We re-examine and generalize the well known model of a ring confined …

Mesoscale, long-time mixing of chromosomes and its connection to polymer dynamics

G Bajpai, S Safran - PLOS Computational Biology, 2023 - journals.plos.org
Chromosomes are arranged in distinct territories within the nucleus of animal cells. Recent
experiments have shown that these territories overlap at their edges, suggesting partial …

[PDF][PDF] Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei

A Wittmeier, C Cassini, M Töpperwien… - Journal of …, 2021 - journals.iucr.org
X-rays are emerging as a complementary probe to visible-light photons and electrons for
imaging biological cells. By exploiting their small wavelength and high penetration depth, it …

Physical properties of the chromosomes and implications for development

T Sugawara, A Kimura - Development, growth & differentiation, 2017 - Wiley Online Library
Remarkable progress has been made in understanding chromosome structures inside the
cell nucleus. Recent advances in Hi‐C technologies enable the detection of genome‐wide …

Generalized Flory Theory for Rotational Symmetry Breaking of Complex Macromolecules

J Kelly, AY Grosberg, R Bruinsma - Physical Review Letters, 2019 - APS
We report on spontaneous rotational symmetry breaking in a minimal model of complex
macromolecules with branches and cycles. The transition takes place as the strength of the …

Elucidating the Contribution of the BAF A12T Mutation to Cellular Mechanisms of Premature Aging

MFM El-Sabban - 2021 - medica-musc.researchcommons.org
The nuclear envelope is a dynamic structure and organizing hub for cell structure and
function. The underlying nuclear lamina is composed of a thick network of intermediate …