Chromatin hydrodynamics
Following recent observations of large scale correlated motion of chromatin inside the nuclei
of live differentiated cells, we present a hydrodynamic theory—the two-fluid model—in which …
of live differentiated cells, we present a hydrodynamic theory—the two-fluid model—in which …
Understanding the dynamics of rings in the melt in terms of the annealed tree model
J Smrek, AY Grosberg - Journal of Physics: Condensed Matter, 2015 - iopscience.iop.org
The dynamical properties of a long polymer ring in a melt of unknotted and unconcatenated
rings are calculated. We re-examine and generalize the well known model of a ring confined …
rings are calculated. We re-examine and generalize the well known model of a ring confined …
Mesoscale, long-time mixing of chromosomes and its connection to polymer dynamics
Chromosomes are arranged in distinct territories within the nucleus of animal cells. Recent
experiments have shown that these territories overlap at their edges, suggesting partial …
experiments have shown that these territories overlap at their edges, suggesting partial …
[PDF][PDF] Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei
A Wittmeier, C Cassini, M Töpperwien… - Journal of …, 2021 - journals.iucr.org
X-rays are emerging as a complementary probe to visible-light photons and electrons for
imaging biological cells. By exploiting their small wavelength and high penetration depth, it …
imaging biological cells. By exploiting their small wavelength and high penetration depth, it …
Physical properties of the chromosomes and implications for development
T Sugawara, A Kimura - Development, growth & differentiation, 2017 - Wiley Online Library
Remarkable progress has been made in understanding chromosome structures inside the
cell nucleus. Recent advances in Hi‐C technologies enable the detection of genome‐wide …
cell nucleus. Recent advances in Hi‐C technologies enable the detection of genome‐wide …
Generalized Flory Theory for Rotational Symmetry Breaking of Complex Macromolecules
J Kelly, AY Grosberg, R Bruinsma - Physical Review Letters, 2019 - APS
We report on spontaneous rotational symmetry breaking in a minimal model of complex
macromolecules with branches and cycles. The transition takes place as the strength of the …
macromolecules with branches and cycles. The transition takes place as the strength of the …
Elucidating the Contribution of the BAF A12T Mutation to Cellular Mechanisms of Premature Aging
MFM El-Sabban - 2021 - medica-musc.researchcommons.org
The nuclear envelope is a dynamic structure and organizing hub for cell structure and
function. The underlying nuclear lamina is composed of a thick network of intermediate …
function. The underlying nuclear lamina is composed of a thick network of intermediate …