The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles
have shown great success in the pharmaceutical industry. Their success is attributed to …

The liposomes have continued to be well-recognized as an important nano-sized drug
delivery system with attractive properties, such a characteristic bilayer structure assembling …

Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of
people around the globe and are a major public health burden. Most contemporary …

Lipid nanoparticles (LNPs) can be designed to potentiate cancer immunotherapy by
promoting their uptake by antigen-presenting cells, stimulating the maturation of these cells …

Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral
gene delivery systems including lipid-based DNA therapeutics offer the opportunity to …

Pyroptosis is closely associated with tumors and inflammatory diseases. By enhancing
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …

It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …

Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-
based gene therapy. Plasmid DNA delivery can result in extended transgene expression …