Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

F Pistollato, S Sumalla Cano, I Elio… - Nutrition …, 2016 - academic.oup.com
It has been hypothesized that alterations in the composition of the gut microbiota might be
associated with the onset of certain human pathologies, such as Alzheimer disease, a …

Plant polyphenols: chemical properties, biological activities, and synthesis

S Quideau, D Deffieux… - Angewandte Chemie …, 2011 - Wiley Online Library
Eating five servings of fruits and vegetables per day! This is what is highly recommended
and heavily advertised nowadays to the general public to stay fit and healthy! Drinking green …

Effects of in vivo conditions on amyloid aggregation

MC Owen, D Gnutt, M Gao, SKTS Wärmländer… - Chemical Society …, 2019 - pubs.rsc.org
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Amyloidogenic protein–membrane interactions: mechanistic insight from model systems

SM Butterfield, HA Lashuel - Angewandte Chemie International …, 2010 - Wiley Online Library
The toxicity of amyloid‐forming proteins is correlated with their interactions with cell
membranes. Binding events between amyloidogenic proteins and membranes result in …

X-ray-based techniques to study the nano–bio interface

C Sanchez-Cano, RA Alvarez-Puebla, JM Abendroth… - ACS …, 2021 - ACS Publications
X-ray-based analytics are routinely applied in many fields, including physics, chemistry,
materials science, and engineering. The full potential of such techniques in the life sciences …

Targeting amyloid aggregation: an overview of strategies and mechanisms

S Giorgetti, C Greco, P Tortora, FA Aprile - International journal of …, 2018 - mdpi.com
Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Protein folding and aggregation into amyloid: the interference by natural phenolic compounds

M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

The β-cell assassin: IAPP cytotoxicity

D Raleigh, X Zhang, B Hastoy… - Journal of molecular …, 2017 - jme.bioscientifica.com
Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …

Mechanisms underlying the antidiabetic activities of polyphenolic compounds: A review

T Nie, GJS Cooper - Frontiers in Pharmacology, 2021 - frontiersin.org
Polyphenolic compounds are thought to show considerable promise for the treatment of
various metabolic disorders, including type 2 diabetes mellitus (T2DM). This review …

Islet amyloid polypeptide: a partner in crime with Aβ in the pathology of alzheimer's disease

AF Raimundo, S Ferreira, IC Martins… - Frontiers in molecular …, 2020 - frontiersin.org
Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …