[HTML][HTML] Mechanisms of hepatocellular carcinoma progression

OO Ogunwobi, T Harricharran, J Huaman… - World journal of …, 2019 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It is
the second leading cause of cancer-related deaths worldwide, with a very poor prognosis. In …

Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy

AK Singh, A Bishayee, AK Pandey - Nutrients, 2018 - mdpi.com
Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and …

TM Al-Noshokaty, NM Mesbah, DM Abo-Elmatty… - Life Sciences, 2022 - Elsevier
Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

NAFLD in the Elderly

SA Alqahtani, JM Schattenberg - Clinical interventions in aging, 2021 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease globally.
Current estimates are that 24% of the adult population, thus, one billion individuals …

[HTML][HTML] Phytochemical, nutraceutical and pharmacological attributes of a functional crop Moringa oleifera Lam: An overview

AK Singh, HK Rana, T Tshabalala, R Kumar… - South African Journal of …, 2020 - Elsevier
Moringa oleifera Lam belonging to family Moringaceae is a plant with high nutritional and
medicinal value. The plant is native to India; however, it is now spread to the tropical and …

Hypericin and its anticancer effects: From mechanism of action to potential therapeutic application

N Choudhary, TE Collignon, D Tewari, A Bishayee - Phytomedicine, 2022 - Elsevier
Background Emerging studies indicate that hypericin has diverse pharmacological actions
and exhibits potential for treatment of various types of cancer. Purpose The current review …

[HTML][HTML] Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review

R Ganguly, A Gupta, AK Pandey - World journal of …, 2022 - ncbi.nlm.nih.gov
Baicalin is a natural bioactive compound derived from Scutellaria baicalensis, which is
extensively used in traditional Chinese medicine. A literature survey demonstrated the broad …

LncRNA CRNDE facilitates epigenetic suppression of CELF2 and LATS2 to promote proliferation, migration and chemoresistance in hepatocellular carcinoma

SC Xie, JQ Zhang, XL Jiang, YY Hua, SW Xie… - Cell death & …, 2020 - nature.com
Our study aimed to investigate the expression, functional significance, and related
mechanism of long noncoding RNA CRNDE (colorectal neoplasia differentially expressed) …

Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer

S Batool, MR Javed, S Aslam, F Noor, HMF Javed… - Pharmaceuticals, 2022 - mdpi.com
Liver cancer (LC), a frequently occurring cancer, has become the fourth leading cause of
cancer mortality. The small number of reported data and diverse spectra of …

Heterogeneity of hepatocellular carcinoma: from mechanisms to clinical implications

F Safri, R Nguyen, S Zerehpooshnesfchi… - Cancer Gene …, 2024 - nature.com
Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …