Chronic infection with Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and
mortality worldwide. HBV-DNA integration into the human genome is recognized as a …

The global burden of hepatitis B virus (HBV) infection remains high, with chronic hepatitis B
(CHB) patients facing a significantly increased risk of developing cirrhosis and …

Background This study aimed to explore the molecular mechanism of the coexistence of
hepatitis B surface antigen (HBsAg) and hepatitis B surface antibody (HBsAb) serological …

HBV integration and function has gradually been expanding. However, the exact mode of
HBV integration remains unclear. In our research, the high-throughput long-read …

Aims Viral integration profiles attract increased interest in the study of HBV-related
hepatocellular carcinoma (HCC), but their features in the early stage of infection and …

Functional explication of genes is of great scientific value. However, conventional methods
have challenges for those genes that may affect biological processes but are not annotated …

Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Dosage
suppressor of NNF1 (DSN1), a component of the MIS12 kinetochore complex, encodes a …

Purpose Few studies have reported the integrated characteristics of hepatitis B virus (HBV)-
related hepatocellular carcinoma (HCC) after long-term antiviral therapy. This study aimed to …

乙型肝炎病毒(HBV) 慢性感染导致肝细胞癌(HCC) 发生发展的机制是典型的癌症进化发育过程.
病毒复制, 变异和整合是HBV 促进HCC 进化的主要途径. HBV 复制激活并维持了慢性炎症微 …

Chronic infection of hepatitis B virus (HBV) is the major cause of hepatocellular carcinoma
(HCC) in China. The occurrence of HCC through chronic inflammation follows the Darwinian …