Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Intestinal barrier in human health and disease

N Di Tommaso, A Gasbarrini, FR Ponziani - International journal of …, 2021 - mdpi.com
The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

The gut microbiota in obesity and weight management: microbes as friends or foe?

M Van Hul, PD Cani - Nature Reviews Endocrinology, 2023 - nature.com
Obesity is caused by a long-term difference between energy intake and expenditure—an
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade

H Tilg, TE Adolph, AR Moschen - Hepatology, 2021 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is an epidemic liver disease, affecting
approximately one quarter of the entire population in the world.(1) This disease …

Gallstone disease, obesity and the firmicutes/bacteroidetes ratio as a possible biomarker of gut dysbiosis

IN Grigor'eva - Journal of personalized medicine, 2020 - mdpi.com
Obesity is a major risk factor for developing gallstone disease (GSD). Previous studies have
shown that obesity is associated with an elevated Firmicutes/Bacteroidetes ratio in the gut …

Gut microbiome, intestinal permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders?

RM Chakaroun, L Massier, P Kovacs - Nutrients, 2020 - mdpi.com
The emerging evidence on the interconnectedness between the gut microbiome and host
metabolism has led to a paradigm shift in the study of metabolic diseases such as obesity …

Emerging concepts in intestinal immune control of obesity-related metabolic disease

S Khan, H Luck, S Winer, DA Winer - Nature Communications, 2021 - nature.com
The intestinal immune system is an important modulator of glucose homeostasis and obesity-
associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites …

The metabolic role and therapeutic potential of the microbiome

LE Olofsson, F Bäckhed - Endocrine reviews, 2022 - academic.oup.com
We are host to an assembly of microorganisms that vary in structure and function along the
length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as …

Bisphenol A (BPA) leading to obesity and cardiovascular complications: a compilation of current in vivo study

R Naomi, MD Yazid, H Bahari, YY Keong… - International journal of …, 2022 - mdpi.com
BPA is one of the most common endocrine disruptors that is widely being manufactured
daily nationwide. Although scientific evidence supports claims of negative effects of BPA on …