Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics
BJM Webb-Robertson, HK Wiberg… - Journal of proteome …, 2015 - ACS Publications
In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
[HTML][HTML] Big data in health care: Applications and challenges
Abstract The concept of Big Data is popular in a variety of domains. The purpose of this
review was to summarize the features, applications, analysis approaches, and challenges of …
review was to summarize the features, applications, analysis approaches, and challenges of …
Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale
Many industrial chemicals that are produced from fossil resources could be manufactured
more sustainably through fermentation. Here we describe the development of a carbon …
more sustainably through fermentation. Here we describe the development of a carbon …
Guide for protein fold change and p-value calculation for non-experts in proteomics
Proteomics studies generate tables with thousands of entries. A significant component of
being a proteomics scientist is the ability to process these tables to identify regulated …
being a proteomics scientist is the ability to process these tables to identify regulated …
Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation
E Nukarinen, T Nägele, L Pedrotti, B Wurzinger… - Scientific Reports, 2016 - nature.com
Since years, research on SnRK1, the major cellular energy sensor in plants, has tried to
define its role in energy signalling. However, these attempts were notoriously hampered by …
define its role in energy signalling. However, these attempts were notoriously hampered by …
The effects of micronutrient deficiencies on bacterial species from the human gut microbiota
Vitamin and mineral (micronutrient) deficiencies afflict 2 billion people. Although the impact
of these imbalances on host biology has been studied extensively, much less is known …
of these imbalances on host biology has been studied extensively, much less is known …
Genomics-informed isolation and characterization of a symbiotic Nanoarchaeota system from a terrestrial geothermal environment
Biological features can be inferred, based on genomic data, for many microbial lineages that
remain uncultured. However, cultivation is important for characterizing an organism's …
remain uncultured. However, cultivation is important for characterizing an organism's …
Large-scale automatic feature selection for biomarker discovery in high-dimensional OMICs data
The identification of biomarker signatures in omics molecular profiling is usually performed
to predict outcomes in a precision medicine context, such as patient disease susceptibility …
to predict outcomes in a precision medicine context, such as patient disease susceptibility …
Simultaneous achievement of high ethanol yield and titer in Clostridium thermocellum
Background Biofuel production from plant cell walls offers the potential for sustainable and
economically attractive alternatives to petroleum-based products. Fuels from cellulosic …
economically attractive alternatives to petroleum-based products. Fuels from cellulosic …
Dramatic performance of Clostridium thermocellum explained by its wide range of cellulase modalities
Clostridium thermocellum is the most efficient microorganism for solubilizing lignocellulosic
biomass known to date. Its high cellulose digestion capability is attributed to efficient …
biomass known to date. Its high cellulose digestion capability is attributed to efficient …