Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes
mellitus is considered as an important risk factor for its development. This risk can be …

The angiopoietin‐like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins
structurally related to factors modulating angiogenesis known as angiopoietins. At first …

Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The
worldwide estimates of its incidence and mortality in the general population are eight cases …

Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the nuclear receptor
superfamily of PPARs (PPARα, PPARβ/δ, PPARγ). Numerous studies have concentrated on …

Background: Peroxisome proliferator-activated receptors (PPARs) have demonstrated a lot
of important effects in the regulation of glucose and lipid metabolism and in the correct …

Background: Available toxicity data can be optimally interpreted if they are integrated using
computational approaches such as systems biology modeling. Such approaches are …

The prevalence of obesity and metabolic diseases (such as type 2 diabetes mellitus,
dyslipidaemia, and cardiovascular diseases) has increased in the last decade, in both …

Cannabinoids (CBs) are used to treat chronic pain, chemotherapy-induced nausea and
vomiting, and multiple sclerosis spasticity. Recently, the medicinal use of CBs has attracted …