Engineering nanosystems to overcome barriers to cancer diagnosis and treatment
Over the past two decades, multidisciplinary investigations into the development of
nanoparticles for medical applications have continually increased. However, nanoparticles …
nanoparticles for medical applications have continually increased. However, nanoparticles …
A patent review of MAPK inhibitors (2018–present)
VR Wydra, RB Ditzinger, NJ Seidler… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The mitogen-activated protein kinase (MAPK) family consist of p38 MAP
kinases, c-Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) …
kinases, c-Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) …
Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine
In clinical settings, cancer vaccines as monotherapies have displayed limited success
compared to other cancer immunotherapeutic treatments. Nanoscale formulations have the …
compared to other cancer immunotherapeutic treatments. Nanoscale formulations have the …
Ciprofloxacin Derivative‐Loaded Nanoparticles Synergize with Paclitaxel Against Type II Human Endometrial Cancer
Combinations of chemotherapeutic agents comprise a clinically feasible approach to combat
cancers that possess resistance to treatment. Type II endometrial cancer is typically …
cancers that possess resistance to treatment. Type II endometrial cancer is typically …
Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAFV600E melanoma-bearing mice
Melanoma, the most malignant form of skin cancer, shows resistance to traditional
anticancer drugs including paclitaxel (PTX). Furthermore, over 50% of melanoma cases …
anticancer drugs including paclitaxel (PTX). Furthermore, over 50% of melanoma cases …
TiO2 nanoparticle as catalyst for an efficient green one-pot synthesis of 1H-3-Indolyl Derivatives as significant antiviral activity
DA Elsayed, MG Assy, SM Mousa, GT El-Bassyouni… - Bioorganic …, 2022 - Elsevier
Abstract Titanium dioxide nanoparticles (TiO 2-NPs) are produced in large quantities for an
extensive range of applications. They retain variable physicochemical properties, which …
extensive range of applications. They retain variable physicochemical properties, which …
Tumor microenvironment and redox dual stimuli-responsive polymeric nanoparticles for the effective cisplatin-based cancer chemotherapy
YY Jia, ML Huan, W Wang, ZY Jia, YH Wan… - …, 2022 - iopscience.iop.org
The serious side effects of cisplatin hindered its clinical application and the nanotechnology
might be the potential strategy to address the limitation. However, rapid clearance in the …
might be the potential strategy to address the limitation. However, rapid clearance in the …
Exploring chemical space, scaffold diversity, and activity landscape of spleen tyrosine kinase active inhibitors
This study aims to comprehensively characterize 576 inhibitors targeting Spleen Tyrosine
Kinase (SYK), a non-receptor tyrosine kinase primarily found in haematopoietic cells, with …
Kinase (SYK), a non-receptor tyrosine kinase primarily found in haematopoietic cells, with …