Cell death: a review of the major forms of apoptosis, necrosis and autophagy
MS D'arcy - Cell biology international, 2019 - Wiley Online Library
Cell death was once believed to be the result of one of two distinct processes, apoptosis
(also known as programmed cell death) or necrosis (uncontrolled cell death); in recent …
(also known as programmed cell death) or necrosis (uncontrolled cell death); in recent …
[HTML][HTML] Lysosomes as a therapeutic target
SR Bonam, F Wang, S Muller - Nature reviews Drug discovery, 2019 - nature.com
Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …
AMPK: guardian of metabolism and mitochondrial homeostasis
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
[HTML][HTML] SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Autophagy: The spotlight for cellular stress responses
Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …
physiological processes including removing of long lived, aggregated and misfolded …
RETRACTED ARTICLE: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
Abstract LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …
[HTML][HTML] A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
[HTML][HTML] Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …
[HTML][HTML] Autophagy and inflammation in ischemic stroke
Y Mo, YY Sun, KY Liu - Neural Regeneration Research, 2020 - journals.lww.com
Appropriate autophagy has protective effects on ischemic nerve tissue, while excessive
autophagy may cause cell death. The inflammatory response plays an important role in the …
autophagy may cause cell death. The inflammatory response plays an important role in the …
Hydroxychloroquine in systemic lupus erythematosus (SLE)
C Ponticelli, G Moroni - Expert opinion on drug safety, 2017 - Taylor & Francis
Introduction: Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that
accumulates in lysosomes where it inhibits some important functions by increasing the pH …
accumulates in lysosomes where it inhibits some important functions by increasing the pH …