The glucose homeostasis system ensures that the circulating glucose level is maintained
within narrow physiological limits both in the fasting (or basal) state and following a nutrient …

BACKGROUND Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within
the islet, but its contribution to islet function in humans remains unknown. We sought to …

Context Glucagon plays a role in the development of type 2 diabetes, yet its role in
prediabetes (preDM) remains uncertain. Objective To evaluate glucagon levels in the fasting …

Protein ingestion concurrently stimulates euglycemic glucagon and insulin secretion, a
response that is particularly robust with rapidly absorbing proteins. Previously, we have …

Background Fasting levels of glucagon are known to be elevated in youth and adults with
type 2 diabetes mellitus (T2D). Children and adolescents with obesity were previously …

Small glycemic increments (≤ 0.5 mmol/L) can exert suppressive actions on endogenous
glucose production (EGP) however it is unclear if this is an insulin dependent or …

In fasting state, glucose metabolism is tightly regulated by a reciprocal bihormonal response,
in 1 which increase in glucose concentration stimulates β-cell insulin secretion and …

The T allele at rs7903146 in TCF7L2 increases the rate of conversion from prediabetes to
type 2 diabetes. This has been associated with impaired β-cell function and with defective …

Context Multiple common genetic variants have been associated with type 2 diabetes, but
the mechanism by which they predispose to diabetes is incompletely understood. One such …

Elevated fasting free fatty acids (FFAs) and fasting glucose are additively associated with
impaired glucose tolerance (IGT) and decreased β-cell function [quantified as disposition …