Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …
supports normal tissue turnover and can mount a regenerative response following acute …
From haematopoietic stem cells to complex differentiation landscapes
E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
Integrated single-cell analysis maps the continuous regulatory landscape of human hematopoietic differentiation
Human hematopoiesis involves cellular differentiation of multipotent cells into progressively
more lineage-restricted states. While the chromatin accessibility landscape of this process …
more lineage-restricted states. While the chromatin accessibility landscape of this process …
Lineage-specific genome architecture links enhancers and non-coding disease variants to target gene promoters
BM Javierre, OS Burren, SP Wilder, R Kreuzhuber… - Cell, 2016 - cell.com
Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …
PacBio sequencing and its applications
A Rhoads, KF Au - Genomics, Proteomics and Bioinformatics, 2015 - academic.oup.com
Single-molecule, real-time sequencing developed by Pacific BioSciences offers longer read
lengths than the second-generation sequencing (SGS) technologies, making it well-suited …
lengths than the second-generation sequencing (SGS) technologies, making it well-suited …
Genetic drivers of epigenetic and transcriptional variation in human immune cells
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …
phenotypes is a major challenge in human genetics and medicine. We carried out high …
[HTML][HTML] RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …
local responses to tumor growth, thereby altering their RNA profile. We determined the …
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
D Pradella, C Naro, C Sette, C Ghigna - Molecular cancer, 2017 - Springer
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
[HTML][HTML] The Human Cell Atlas bone marrow single-cell interactive web portal
Highlights•Interactive resource for bone marrow donor variation between cell
populations.•Deep evaluation of Human Cell Atlas (HCA) data spanning eight donors and …
populations.•Deep evaluation of Human Cell Atlas (HCA) data spanning eight donors and …