Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …

Abstract Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the
endoplasmic reticulum, where they impact Ca2+ dynamics by controlling IP3 receptor (IP3R) …

Members of the Bcl-2-protein family are key controllers of apoptotic cell death. The family is
divided into antiapoptotic (including Bcl-2 itself, Bcl-xL, Mcl-1, etc.) and proapoptotic …

Increasing global food production is threatened by harsh environmental conditions along
with biotic stresses, requiring massive new research into integrated stress resistance in …

Abstract The inositol 1, 4, 5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …

Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating
circadian rhythm and involved in multiple heart diseases. However, it is unknown whether …

The family of B-cell lymphoma-2 (Bcl-2) proteins exerts key functions in cellular health. Bcl-2
primarily acts in mitochondria where it controls the initiation of apoptosis. However, during …

The folding capacity of membrane and secretory proteins in the endoplasmic reticulum (ER)
can be challenged by physiological and pathological perturbations, causing ER stress. If …

The endoplasmic reticulum (ER) and mitochondria are essential intracellular organelles that
actively communicate via temporally and spatially formed contacts called mitochondria …