The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Adequate oxygen supply is essential for the human brain to meet its high energy demands.
Therefore, elaborate molecular and systemic mechanism are in place to enable adaptation …

Plants are aerobic organisms that require oxygen for their respiration. Hypoxia arises due to
the insufficient availability of oxygen, and is sensed by plants, which adapt their growth and …

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

Changes in body composition and weight loss frequently occur when humans are exposed
to hypoxic environments. The mechanisms thought to be responsible for these changes are …

Although not a barrier to perform sport, cold weather environments (low ambient
temperature, high wind speeds, and increased precipitation, ie, rain/water/snow) may …

Understanding the biological mechanisms of climatic adaptation is of paramount importance
for the optimization of breeding programs and conservation of genetic resources. The aim of …

Simple Summary The yak is a multipurpose domesticated animal that serves as a protein
source for local herders and a sacred carrier of culture and religion. Besides their economic …