Calcific aortic valve disease (CAVD) is the end result of active cellular processes that lead to
the progressive fibrosis and calcification of aortic valve leaflets. In western populations …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Reactive oxygen species (ROS), a by-product of aerobic life, are highly reactive molecules
with unpaired electrons. The excess of ROS leads to oxidative stress, instigating the …

Mn (III) ortho‐N‐alkyl‐and N‐alkoxyalkyl porphyrins (MnPs) were initially developed as
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …

Superoxide dismutases play an important role in human health and disease. Three decades
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …

Despite the elucidation of the pathways behind the development of aortic stenosis (AS),
there remains no effective medical treatment to slow or reverse its progress. Instead, the …

Introduction Oxidative stress due to excess reactive oxygen species (ROS) is related to
many chronic illnesses including degenerative disc disease and osteoarthritis. MnTnBuOE-2 …

Reactive oxygen species (ROS) cause oxidative stress by generating reactive aldehydes
known as 4-hydroxynonenal (4-HNE). 4-HNE modifies protein via covalent adduction; …

For such a thin tissue, the aortic valve possesses an exquisitely complex, multi-layered
extracellular matrix (ECM), and disruptions to this structure constitute one of the earliest …

Calcific aortic valve disease (CAVD) is a major cause of cardiovascular mortality and
morbidity, with increased prevalence and incidence. The underlying mechanisms behind …