Envenomation via snakebites is an important public health problem in many tropical and
subtropical countries that, in addition to mortality, can result in permanent sequelae as a …

Phospholipases A2 (PLA2s) are commonly found in snake venoms from Viperidae,
Hydrophidae and Elaphidae families and have been extensively studied due to their …

MjTX-II, a myotoxic phospholipase A2 (PLA2) homologue from Bothrops moojeni venom,
was functionally and structurally characterized. The MjTX-II characterization included:(i) …

Phospholipase A2 (PLA2, EC 3.1. 1.4), a major component of snake venoms, specifically
catalyzes the hydrolysis of fatty acid ester bonds at position 2 of 1, 2-diacyl-sn-3 …

Viperid venoms often contain mixtures of Asp49 and Lys49 PLA 2 myotoxin isoforms,
relevant to development of myonecrosis. Given their difference in catalytic activity …

New 3-substituted oxindole derivatives were designed and synthesized as antiproliferative
agents. The antiproliferative activity of compounds 6a–j was evaluated against 60 NCI cell …

Abstract Crotoxin B (CB or Cdt PLA2) is a basic Asp49‐PLA2 found in the venom of Crotalus
durissus terrificus and it is one of the subunits that constitute the crotoxin (Cro). This …

Viper venom phospholipase A2 enzymes (vvPLA2s) and phospholipase A2-like (PLA2-like)
proteins are two of the principal toxins in viper venom that are responsible for the severe …

This paper describes a biochemical and pharmacological characterization of BpirPLA 2-I,
the first acidic Asp49-PLA 2 isolated from Bothrops pirajai. BpirPLA 2-I caused hypotension …

This article reports the purification procedure and the biochemical/functional
characterization of Bp-PLA2, a new myotoxic acidic phospholipase A2 from Bothrops …