Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Sleep disorders are among the most common non-motor manifestations in Parkinson's
disease (PD) and have a significant negative impact on quality of life. While sleep disorders …

Parkinson's disease has a long prodromal stage with various subclinical motor and non-
motor manifestations; however, their evolution in the years before Parkinson's disease is …

Importance There is increasing evidence that Parkinson disease (PD) is heterogeneous in
its clinical presentation and prognosis. Defining subtypes of PD is needed to better …

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …

Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with
numerous studies highlighting the importance of NMS both in “pre-motor” phase of PD as …

With advances in knowledge disease, boundaries may change. Occasionally, these
changes are of such a magnitude that they require redefinition of the disease. In recognition …

Objective This multilanguage study used simple speech recording and high‐end pattern
analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus …

Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …

Objective: We investigated an array of possible markers of early dementia in Parkinson
disease. Methods: We performed a comprehensive assessment of autonomic, sleep …