Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Transient receptor potential canonical type 6 (TRPC6) is a nonselective receptor-operated
cation channel that regulates reactive fibrosis and growth signaling. Increased TRPC6 …

Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein
and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells …

More than a century of research on the Frank–Starling Law has significantly advanced our
knowledge about the working heart. The Frank–Starling Law mandates that the heart is able …

Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Duchenne muscular dystrophy (DMD) is a genetic muscle disorder caused by mutations in
the Dmd gene resulting in the loss of the protein dystrophin. Patients do not only experience …

Endothelial cells and smooth muscle cells of resistance arteries mediate opposing
responses to mechanical forces acting on the vasculature, promoting dilation in response to …

Rationale: The cellular and molecular basis for post–myocardial infarction (MI) structural and
functional remodeling is not well understood. Objective: Our aim was to determine if Ca2+ …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …