In neuroscience, Ephs and ephrins are perhaps best known for their role in axon guidance. It
was first shown in the visual system that graded expression of these proteins is instrumental …

SUMMARY A growing body of evidence supports the 'calcium hypothesis' of Alzheimer's
disease (AD), which postulates that a variety of insults might disrupt the homeostatic …

Amyloid precursor protein (APP) belongs to a family of evolutionarily conserved
transmembrane glycoproteins that has been proposed to regulate multiple aspects of cell …

Abstract Follicle-stimulating hormone (FSH)-mediated changes in granulosa cell adhesion
and morphology are essential for preovulatory follicle development, given the dramatic …

Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ)
peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate …

Amyloid precursor protein (APP) was originally identified as the source of β-amyloid
peptides that accumulate in Alzheimer's disease (AD), but it also has been implicated in the …

Postmitotic neurons in the neocortex migrate to appropriate positions and form layered
structures of nascent cortex during brain development. The migration of these neurons …

The coordination of neuronal and glial migration is essential to the formation of most
nervous systems, requiring a complex interplay of cell-intrinsic responses and intercellular …

Reverse signaling via glycosylphosphatidylinositol (GPI)-linked Ephrins may help control
cell proliferation and outgrowth within the nervous system, but the mechanisms underlying …

The Eph family of receptor tyrosine kinases and their cognate ligands, the Ephrins, form a
coordinated program of cell contact-mediated migration control, polarity establishment, and …