Aortic stenosis is a common, potentially fatal condition that is set to become an increasing
public health burden. Once symptoms develop, there is an inexorable deterioration with a …

Calcific aortic valve stenosis (CAVS) is common in the ageing population and set to become
an increasing economic and health burden. Once present, it inevitably progresses and has a …

Background The use of non-invasive imaging to identify ruptured or high-risk coronary
atherosclerotic plaques would represent a major clinical advance for prevention and …

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart
valves but their susceptibility to structural valve degeneration (SVD) limits their use in young …

Background—18F-Sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) are
promising novel biomarkers of disease activity in aortic stenosis. We compared 18F-NaF …

Background Aortic valve stenosis is a progressive disorder with variable progression rates.
The factors affecting aortic stenosis (AS) progression remain largely unknown. Objectives …

Background: Microcalcifications in atherosclerotic plaques are destabilizing, predict adverse
cardiovascular events, and are associated with increased morbidity and mortality. 18F …

Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …

Major focus has been placed on the identification of vulnerable plaques as a means of
improving the prediction of myocardial infarction. However, this strategy has recently been …

Background: Calcification of the aortic valve leads to increased leaflet stiffness and
consequently to the development of calcific aortic valve disease. However, the underlying …