New tetradentate Schiff base transition metal complexes have been derived from
salicylidene-4-imino-2, 3-dimethyl-1-phenyl-3-pyrazolin-5-one and histidine were …

Piper nigrum, or black pepper, produces piperine, an alkaloid that has diverse
pharmacological activities. In this study, N-aryl amide piperine analogs were prepared by …

Increased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely
linked to the neurodegeneration observed in Parkinson's Disease (PD). Caffeic acid (CA) …

Piperine has been associated with neuroprotective effects and monoamine oxidase (MAO)
inhibition, thus being an attractive scaffold to develop new antiparkinsonian agents …

Polypharmacology is a new trend in amyotrophic lateral sclerosis (ALS) therapy and an
effective way of addressing a multifactorial etiology involving excitotoxicity, mitochondrial …

Natural products are an invaluable source for the discovery of drug and pesticide
candidates. Piperine, a simple and pungent alkaloid, is isolated from several plants of …

Chromone-3-phenylcarboxamides (Crom-1 and Crom-2) were identified as potent, selective,
and reversible inhibitors of human monoamine oxidase B (h MAO-B). Since they exhibit …

Currently, black pepper commands the leading position among all the spices as a spice of
great commercial importance in all the world trade and finds its way into the dietary habits of …

With the goal of combating the multi-faceted Alzheimer's disease (AD), a series of
Rivastigmine-Benzimidazole (RIV–BIM) hybrids was recently reported by us as multitarget …

Neurotransmitter depletion and mitochondrial dysfunction are among the multiple
pathological events that lead to neurodegeneration. Following our previous studies related …