Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …

DNA replication in eukaryotes is strictly regulated by several mechanisms. A central step in
this replication is the assembly of the heterohexameric minichromosome maintenance …

A family of six homologous subunits, Mcm2,-3,-4,-5,-6, and-7, each with its own unique
features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six …

The central step in the initiation of eukaryotic DNA replication is the loading of the
minichromosome maintenance 2–7 (MCM2-7) complex, the core of the replicative DNA …

ABSTRACT DNA replication is a key biological process that involves different protein
complexes whose assembly is rigorously regulated in a successive order. One of these …

Cell division is a complex process that requires precise duplication of genetic material.
Duplication is concerted by replisomes. The Minichromosome Maintenance (MCM) …

Abstract Myeloid cell leukemia 1 (MCL-1) is an anti-apoptotic BCL-2 family protein
implicated in the development, maintenance, and chemoresistance of human cancer. MCL-1 …

All living organisms need to duplicate their genetic material prior to cell division in order to
maintain genomic-stability. Cells have evolved sophisticated DNA replication mechanisms …

Ribosomes are the universal machines which perform mRNA translation inside the cell.
Chloroplasts harbor bacterial-like 70S ribosome but have acquired five plastid-specific …

In eukaryotes, a crucial step during the initiation of DNA replication is the timely formation
and activation of the replicative DNA helicase composed of Cdc45, MCM2-7 and GINS …