Reservoir host immune responses to emerging zoonotic viruses
Zoonotic viruses, such as HIV, Ebola virus, coronaviruses, influenza A viruses, hantaviruses,
or henipaviruses, can result in profound pathology in humans. In contrast, populations of the …
or henipaviruses, can result in profound pathology in humans. In contrast, populations of the …
The biology of monocytes and dendritic cells: contribution to HIV pathogenesis
Myeloid cells such as monocytes, dendritic cells (DC) and macrophages (MΦ) are key
components of the innate immune system contributing to the maintenance of tissue …
components of the innate immune system contributing to the maintenance of tissue …
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
dynamics and cell–cell cooperativity in evolving human immune responses remain poorly …
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection
FJ Barrat, L Su - Journal of Experimental Medicine, 2019 - rupress.org
Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary
ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed …
ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed …
Type I interferon: understanding its role in HIV pathogenesis and therapy
SE Bosinger, NS Utay - Current HIV/AIDS Reports, 2015 - Springer
Despite over 30 years of research, the contribution of type I interferons (IFN-Is) to both the
control of HIV replication and initiation of immunologic damage remains debated. In acute …
control of HIV replication and initiation of immunologic damage remains debated. In acute …
Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment
J Rappaport, DJ Volsky - Journal of neurovirology, 2015 - Springer
Combination antiretroviral therapy (ART) has altered the outcomes of HIV infection in treated
populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV …
populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV …
Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host
D Palesch, SE Bosinger, GK Tharp, TH Vanderford… - Nature, 2018 - nature.com
In contrast to infections with human immunodeficiency virus (HIV) in humans and simian
immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys …
immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys …
The role of toll-like receptors in retroviral infection
EP Browne - Microorganisms, 2020 - mdpi.com
Toll-like receptors (TLRs) are key pathogen sensing receptors that respond to diverse
microbial ligands, and trigger both innate and adaptive immune responses to infection …
microbial ligands, and trigger both innate and adaptive immune responses to infection …
Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection
B Jacquelin, G Petitjean, D Kunkel, AS Liovat… - PLoS …, 2014 - journals.plos.org
Chronic immune activation (IA) is considered as the driving force of CD4+ T cell depletion
and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of …
and AIDS. Fundamental clues in the mechanisms that regulate IA could lie in natural hosts of …