Dysfunction of immune responses has been identified to involve in the pathogenesis of
various neurodegenerative diseases. Abnormal activation of glia cells and/or infiltration of …

There exists an urgent need for effective treatments for those patients suffering from
chronic/progressive multiple sclerosis (MS). Accordingly, it has become readily apparent that …

Demyelination and remyelination play pivotal roles in the pathological process of multiple
sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), a well-established …

Background Multiple sclerosis (MS) is a demyelinating disease with a wide range of
symptoms including walking impairment and neuropathic pain mainly represented by …

Leukodystrophies are often devastating diseases, presented with progressive clinical signs
as spasticity, ataxia and cognitive decline, and lack proper treatment options. New therapy …

The preclinical selection of therapeutic candidates for progressive multiple sclerosis (MS)
would be aided by the development of sensitive behavioural measures that accurately …

Multiple sclerosis (MS) is a progressive and debilitating neurological condition in which the
immune system abnormally attacks the myelin sheath insulating the nerves. Mesenchymal …

Recent evidence suggests that clozapine and quetiapine (atypical antipsychotics), tamoxifen
(selective-estrogen receptor modulator) and pioglitazone (PPARγ agonist) may improve …

Background and Purpose: Multiple sclerosis (MS) is an autoimmune disorder characterized
by demyelination and axonal loss. Quantitative estimation of behavioral, locomotor, and …

To date, no studies have explored the effect of abnormal cerebral venous circulation on
brain disorders, whereas many studies have investigated neurodegenerative brain …