Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

COVID-19 and diabetes mellitus: from pathophysiology to clinical management

S Lim, JH Bae, HS Kwon, MA Nauck - Nature Reviews Endocrinology, 2021 - nature.com
Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in patients …

American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Diagnosis and management of prediabetes: a review

JB Echouffo-Tcheugui, L Perreault, L Ji… - Jama, 2023 - jamanetwork.com
Importance Prediabetes, an intermediate stage between normal glucose regulation and
diabetes, affects 1 in 3 adults in the US and approximately 720 million individuals …

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

DL Eizirik, L Pasquali, M Cnop - Nature Reviews Endocrinology, 2020 - nature.com
Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

Type 2 diabetes and its impact on the immune system

A Berbudi, N Rahmadika, AI Tjahjadi… - Current diabetes …, 2020 - ingentaconnect.com
Introduction: Type 2 Diabetes (T2D) is a major health problem worldwide. This metabolic
disease is indicated by high blood glucose levels due to insufficient insulin production by the …

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

R Wagner, M Heni, AG Tabak, J Machann, F Schick… - Nature medicine, 2021 - nature.com
The state of intermediate hyperglycemia is indicative of elevated risk of developing type 2
diabetes. However, the current definition of prediabetes neither reflects subphenotypes of …

COVID-19 and preexisting comorbidities: risks, synergies, and clinical outcomes

B Bigdelou, MR Sepand, S Najafikhoshnoo… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated
symptoms, named coronavirus disease 2019 (COVID-19), have rapidly spread worldwide …