The field of epigenetics studies the complex processes that regulate gene expression
without altering the DNA sequence itself. It is well established that epigenetic modifications …

Graft-versus-host disease (GVHD) is a common complication after allogeneic hematopoietic
stem cell transplantation. Recent studies have reported that protein arginine …

EZH2 is a histone methyltransferase. It catalyzes trimethylation of histone H3 at lysine 27
(H3K27me3) to control gene transcription critical for cell proliferation, differentiation …

Allogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative
treatment for various hematologic malignancies. However, graft-versus-host disease …

In the extensive literature characterizing lymphocyte contributions to transplant-related
pathologies including allograft rejection and graft-versus-host disease, T cell–focused …

Bronchiolitis obliterans syndrome (BOS) is a chronic complication following lung
transplantation that limits the long-term survival. Although the enhancer of zeste homolog 2 …

In the epigenetic regulation of gene expression, post-translational modifications such as
phosphorylation, methylation, acetylation, and ubiquitination to DNA and histones that …

In this issue of Blood, Zaiken et al describe the impact on chronic graft-versus-host disease
(cGVHD) affecting the formation of germinal centers (GCs) in secondary lymphoid organs …

In a recent issue of Blood (Blood 139, 2022), Zaiken et al 1 reported that in vivo
administration of the EZH2 inhibitor JQ5 effectively reduces chronic graft-versus-host …

GKHIVNAUVKXIIY-UHFFFAOYSA-N 2-[3-[4-(1h-indazol-5-ylamino) quinazolin-2-yl]
phenoxy]-n-propan-2-ylacetamide Chemical group CC (C) NC (= O) COC1= CC= CC (C …