Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
RANKL biology: bone metabolism, the immune system, and beyond
T Ono, M Hayashi, F Sasaki, T Nakashima - Inflammation and …, 2020 - Springer
Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …
Thymic epithelial cells
J Abramson, G Anderson - Annual review of immunology, 2017 - annualreviews.org
Intrathymic T cell development is a complex process that depends upon continuous
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …
RANKL biology
N Takegahara, H Kim, Y Choi - Bone, 2022 - Elsevier
Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …
Thymic B cells are licensed to present self antigens for central T cell tolerance induction
T Yamano, J Nedjic, M Hinterberger, M Steinert… - Immunity, 2015 - cell.com
Thymic antigen-presenting cells (APCs) such as dendritic cells and medullary thymic
epithelial cells (mTECs) use distinct strategies of self-antigen expression and presentation to …
epithelial cells (mTECs) use distinct strategies of self-antigen expression and presentation to …
Tissue-specific distribution of iNKT cells impacts their cytokine response
Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2,
and NKT17, which produce distinct cytokines when stimulated, but little is known about their …
and NKT17, which produce distinct cytokines when stimulated, but little is known about their …
Invariant natural killer T cell subsets—more than just developmental intermediates
Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond
to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This …
to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This …
Twenty years of AIRE
R Perniola - Frontiers in immunology, 2018 - frontiersin.org
About two decades ago, cloning of the autoimmune regulator (AIRE) gene materialized one
of the most important actors on the scene of self-tolerance. Thymic transcription of genes …
of the most important actors on the scene of self-tolerance. Thymic transcription of genes …
Immune networks and therapeutic targeting of iNKT cells in cancer
SI Fujii, K Shimizu - Trends in immunology, 2019 - cell.com
One of the primary goals in tumor immunotherapy is to reset the immune system from
tolerogenic to immunogenic–a process in which invariant natural killer T (iNKT) cells are …
tolerogenic to immunogenic–a process in which invariant natural killer T (iNKT) cells are …
CCR7 defines a precursor for murine iNKT cells in thymus and periphery
H Wang, KA Hogquist - Elife, 2018 - elifesciences.org
The precise steps of iNKT subset differentiation in the thymus and periphery have been
controversial. We demonstrate here that the small proportion of thymic iNKT and mucosal …
controversial. We demonstrate here that the small proportion of thymic iNKT and mucosal …