Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the
United States and formation of APAP-protein adducts, mitochondrial oxidant stress and …

Background: The liver has a number of functions in innate immunity. These functions
predispose the liver to innate immune-mediated liver injury when inflammation goes …

The toxicity induced by the persistent organic pollutants per-and polyfluoroalkyl substances
(PFAS) is dependent on the length of their polyfluorinated tail. Long-chain PFASs have …

Microphysiological systems (MPS), such as organ-on-a-chip platforms, are an emerging
alternative model that may be useful for predicting human physiology and/or toxicity. Due to …

Acetaminophen (APAP) overdose causes hepatotoxicity involving mitochondrial dysfunction.
Previous studies showed that translocation of Fe 2+ from lysosomes into mitochondria by the …

This book is a continuance of the topic:“DAMPs in Human Diseases”, the basics of which
were described in a first volume by the same author. This second volume presents our …

Mitochondrial dysfunction has been implicated in acute, severe liver injury caused by
overdose of acetaminophen (APAP). However, whether mitochondrial biogenesis is …

Acetaminophen (APAP) is a common analgesic, but overdose of the drug is the main cause
of acute liver failure in the United States and other Western countries. The mechanism of …

Las nanopartículas (NP) se han investigado por su tamaño diminuto y su posibilidad de
llegar a sitios específicos. Se estudian materiales para diseñar nanovectores inocuos. Son …

In this chapter, traumatic and nontraumatic solid organ injuries (including examples of drug-
induced and alcohol-related organ injuries) known to cause acute or chronic diseases are …