Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

The localization of mRNAs to subcellular compartments provides a mechanism for
regulating gene expression with exquisite temporal and spatial control. Recent studies …

Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

Ribosome synthesis is a highly complex and coordinated process that occurs not only in the
nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells. Based on the …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

Duplicated genes escape gene loss by conferring a dosage benefit or evolving diverged
functions. The yeast Saccharomyces cerevisiae contains many duplicated genes encoding …

Cytoplasmic mRNA localization provides a means of generating cell asymmetry and
segregating protein activity. Previous studies have identified two mRNAs that localize to the …

The pathway and complete collection of factors that orchestrate ribosome assembly are not
clear. To address these problems, we affinity purified yeast preribosomal particles …

In eukaryotic cells, proteins are targeted to their final subcellular locations with precise
timing. A key underlying mechanism is the active transport of cognate mRNAs, which in …

Background: mRNA localization in somatic cells is an important mechanism for gene
expression regulation. In fibroblasts, the protein ZBP1 associates with the sequence that …