Thyroid malignancies are the most common endocrine system carcinomas, with four
histopathological forms. The phosphoinositide 3-kinase–protein kinase B/AKT (PI3K …

Induced pluripotent stem (iPS) cells, somatic cells reprogrammed to the pluripotent state by
forced expression of defined factors, represent a uniquely valuable resource for research …

Apoptosis is a highly conserved biochemical mechanism which is tightly controlled in cells. It
contributes to maintenance of tissue homeostasis and normally eliminates highly …

Background aims Acute liver failure (ALF), a life-threatening disease characterized by the
sudden loss of hepatic function, can occur after an accidental or intentional acetaminophen …

Background A specific 3-dimensional intrachromosomal architecture of core stem cell factor
genes is required to reprogram a somatic cell into pluripotency. As little is known about the …

Crosstalk between intracellular signaling pathways has been extensively studied to
understand the pluripotency of human pluripotent stem cells (hPSCs), including human …

Histone deacetylase inhibitor valproic acid (VPA) has been used to increase the
reprogramming efficiency of induced pluripotent stem cell (iPSC) from somatic cells, yet the …

Background: Long non-coding RNAs (lncRNAs) constitute an important component of the
regulatory apparatus that controls stem cell pluripotency. However, the specific mechanisms …

Long noncoding RNAs (lncRNAs) can regulate the activity of target genes by participating in
the organization of chromatin architecture. We have devised a “chromatin-RNA in situ …

To efficiently prevent diabetic cardiomyopathy (DCM), we have explored and confirmed that
metallothionein (MT) prevents DCM by attenuating oxidative stress, and increasing …