Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of
certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non …

IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

Rheumatoid arthritis (RA) is a systemic auto-immune disease principally effecting synovial
joints. RA is characterized by immune cell infiltration in the joint. The presence of …

Antibodies and Fc-fusion antibody-like proteins have become successful biologics
developed for cancer treatment, passive immunity against infection, addiction, and …

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …

CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid
leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting …

Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An
important aspect of antibodies is their ability to bind antigen while at the same time recruit …

Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …

Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …