Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …

Random monoallelic expression (RME) of genes represents a striking example of how
stochastic molecular processes can result in cellular heterogeneity. Recent transcriptome …

DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …

Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …

Cellular heterogeneity can emerge from the expression of only one parental allele.
However, it has remained controversial whether, or to what degree, random monoallelic …

Genes are typically assumed to express both parental alleles similarly, yet cell lines show
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …

Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …

We propose an evolutionary perspective to classify and characterize the diverse systems of
adaptive immunity that have been discovered across all major domains of life. We put …

Monoallelic gene expression is a remarkable process in which transcription occurs from only
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …

Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …