[HTML][HTML] The molecular and cellular origin of human prostate cancer
JR Packer, NJ Maitland - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …
epidemiology, there are no definitive aetiological clues linking development to frequency …
Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation
B Reinius, R Sandberg - Nature Reviews Genetics, 2015 - nature.com
Random monoallelic expression (RME) of genes represents a striking example of how
stochastic molecular processes can result in cellular heterogeneity. Recent transcriptome …
stochastic molecular processes can result in cellular heterogeneity. Recent transcriptome …
[HTML][HTML] Gene body methylation can alter gene expression and is a therapeutic target in cancer
DNA methylation in promoters is well known to silence genes and is the presumed
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
therapeutic target of methylation inhibitors. Gene body methylation is positively correlated …
The landscape of genomic imprinting across diverse adult human tissues
Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA–seq
Cellular heterogeneity can emerge from the expression of only one parental allele.
However, it has remained controversial whether, or to what degree, random monoallelic …
However, it has remained controversial whether, or to what degree, random monoallelic …
Random allelic expression in the adult human body
SN Kravitz, E Ferris, MI Love, A Thomas, AR Quinlan… - Cell reports, 2023 - cell.com
Genes are typically assumed to express both parental alleles similarly, yet cell lines show
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
random allelic expression (RAE) for many autosomal genes that could shape genetic effects …
Incomplete penetrance in primary immunodeficiency: a skeleton in the closet
C Gruber, D Bogunovic - Human genetics, 2020 - Springer
Primary immunodeficiencies (PIDs) comprise a diverse group of over 400 genetic disorders
that result in clinically apparent immune dysfunction. Although PIDs are classically …
that result in clinically apparent immune dysfunction. Although PIDs are classically …
An evolutionary perspective on the systems of adaptive immunity
We propose an evolutionary perspective to classify and characterize the diverse systems of
adaptive immunity that have been discovered across all major domains of life. We put …
adaptive immunity that have been discovered across all major domains of life. We put …
Random monoallelic expression: regulating gene expression one allele at a time
MA Eckersley-Maslin, DL Spector - Trends in Genetics, 2014 - cell.com
Monoallelic gene expression is a remarkable process in which transcription occurs from only
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …
Constitutional epimutation as a mechanism for cancer causality and heritability?
MP Hitchins - Nature Reviews Cancer, 2015 - nature.com
Constitutional epimutation, which is an aberration in gene expression due to an altered
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …
epigenotype that is widely distributed in normal tissues (albeit frequently mosaic), provides …