The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …

Deep understanding of the pathophysiological role of the mitochondrial respiratory chain
(MRC) relies on a well-grounded model explaining how its biogenesis is regulated. The lack …

The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …

Respiratory complex I is a~ 1-MDa proton pump in mitochondria. Its structure has been
revealed in great detail, but the structural basis of its assembly, in humans involving at least …

Neurons are extremely energy demanding cells and highly dependent on the mitochondrial
oxidative phosphorylation (OXPHOS) system. Mitochondria generate the energetic potential …