Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in
fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a …

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative
alterations of the microvasculature leading to fibrosis and loss of function of the skin and …

In patients with systemic sclerosis (SSc), gastrointestinal (GI)-tract involvement is almost
universal. Any segment of the GI tract from mouth to anus can be involved, and GI symptoms …

Here, we provide important updates pertaining to the risk stratification, assessment,
diagnosis and management of SSc patients with gastrointestinal symptoms. These findings …

Background Data on the neuromodulatory effects of brain‐derived neurotrophic factor
(BDNF) in the gastrointestinal tract were recently reported, but there are still no data on the …

Background Gastrointestinal tract (GIT) involvement is a common cause of debilitating
symptoms in patients with systemic sclerosis (SSc). There are no disease modifying …

Isolated tissue bath assays are a classical pharmacological tool for evaluating concentration-
response relationships in a myriad of contractile tissues. While this technique has been …

Nearly all patients with systemic sclerosis (SSc) are negatively affected by dysfunction in the
gastrointestinal tract, and the severity of gastrointestinal disease in SSc correlates with high …

Gastrointestinal (GI) involvement is frequent in scleroderma (systemic sclerosis [SSc]) and is
the most frequent internal complication of the disease. Patients with GI involvement have …

The identification of individuals with systemic sclerosis in an oligosymptomatic phase
preceding the very early manifestations of the disease represents a challenge in the search …