Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. The
progression of renal lesions to fibrosis involves several mechanisms, among which the …

Transforming growth factor beta is a multifunctional polypeptide growth factor implicated in a
variety of renal diseases. The expression of transforming growth factor beta is enhanced in …

TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast
growth factor (FGF-2). Background The prognosis of primary renal disease is often …

Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.
Background Aldosterone promotes nephrosclerosis in several rat models, whereas …

Reactive oxygen species mediate high glucose–induced plasminogen activator inhibitor-1
up-regulation in mesangial cells and in diabetic kidney. Background Plasminogen activator …

Modulation of plasminogen activator inhibitor-1 in vivo: A new mechanism for the anti-fibrotic
effect of renin-angiotensin inhibition. We examined the potential of in vivo linkage of …

The pathogenesis of autoantibody-mediated cellular and tissue lesions in autoimmune
diseases is most straightforwardly attributable to the combined action of self-antigen binding …

Hyperoxia-induced lung disease is associated with prominent intraalveolar fibrin deposition.
Fibrin turnover is tightly regulated by the concerted action of proteases and antiproteases …

Plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) are the
major regulators of plasmin generation. Glomerular PAI-1/tPA balance is involved in …

Human placenta‐derived mesenchymal stem cells (pMSCs) are considered a good source
for cell therapy. The purpose of this study was to observe whether the transplantation of …