Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

The extracellular matrix (ECM) is a living network of proteins that maintains the structural
integrity of the myocardium and allows the transmission of electrical and mechanical forces …

We propose that stage D advanced heart failure be defined as the presence of progressive
and/or persistent severe signs and symptoms of heart failure despite optimized medical …

Myocarditis is defined clinically as inflammation of the heart muscle. First introduced into the
medical literature at the beginning of the 19th century, the term “myocarditis” was initially …

Background: Interstitial fibrosis is an important component of diastolic, and systolic,
dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts …

Background In patients with severe heart failure, prolonged unloading of the myocardium
with the use of a left ventricular assist device has been reported to lead to myocardial …

Depressed contractility is a central feature of the failing human heart and has been attributed
to altered [Ca2+] i. This study examined the respective roles of the L-type Ca2+ current (I …

In the heart, autophagy is required for normal cardiac function and also has been implicated
in cardiovascular disease. FoxO transcription factors promote autophagy in skeletal muscle …

Heart failure (HF) involves changes in cardiac structure, myocardial composition, myocyte
deformation, and multiple biochemical and molecular alterations that impact heart function …

This review provides a comprehensive overview of the past 25+ years of research into the
development of left ventricular assist device (LVAD) to improve clinical outcomes in patients …