Spinal muscular atrophy is an autosomal recessive neurodegenerative disease
characterised by degeneration of spinal cord motor neurons, atrophy of skeletal muscles …

Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes.
One such disorder, spinal muscular atrophy, is caused by loss or mutation of the survival …

The identification of interaction partners in protein complexes is a major goal in cell biology.
Here we present a reliable affinity purification strategy to identify specific interactors that …

As neurons are one of the most highly polarized cells in our body, they require sophisticated
cellular mechanisms to maintain protein homeostasis in their subcellular compartments such …

Spinal muscular atrophy (SMA) is caused by mutations of the survival of motor neuron
(SMN1) gene and deficiency of full-length SMN protein (FL-SMN). All SMA patients retain …

Spinal muscular atrophy (SMA) results from reduced levels of the survival of motor neuron
(SMN) protein, which has a well characterized function in spliceosomal small nuclear …

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by homozygous
mutations or deletions in the survival of motor neuron (SMN1) gene, encoding the …

Spliceosomal snRNPs are multicomponent particles that undergo a complex maturation
pathway. Human Sm-class snRNAs are generated as 3′-end extended precursors, which …

The Cajal body, originally identified over 100 years ago as a nucleolar accessory body in
neurons, has come to be identified with nucleoplasmic structures, often quite tiny, that …

Spinal muscular atrophy is an autosomal-recessive neuromuscular disease caused by
disruption of the survival of motor neuron (SMN) gene, which promotes cytoplasmic …