Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

[HTML][HTML] Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation

AC Famurewa, K Renu, MA Eladl… - Biomedicine & …, 2022 - Elsevier
Toxic heavy metals (THMs) are non-essential hazardous environmental pollutants with
intractable health challenges in humans and animals. Exposure to lead (Pb), cadmium (Cd) …

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of Translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the …

C Gur, SA Akarsu, N Akaras, SC Tuncer… - Environmental …, 2023 - Wiley Online Library
Arsenic (As) is a highly toxic metalloid. Carvacrol (CAR) is the active ingredient of
Lamiaceae plants and has various biological and pharmacological properties. The present …

Naringin and Hesperidin Counteract Diclofenac‐Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti‐Inflammatory, and Antiapoptotic Activities

RA Hassan, WG Hozayen, HT Abo Sree… - Oxidative medicine …, 2021 - Wiley Online Library
This study is aimed at evaluating the preventive effect and at suggesting the mode of actions
of naringin and hesperidin and their combination in diclofenac‐induced hepatotoxicity. Male …

[HTML][HTML] Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-ß/Smads and Ang-1/Tie-2 …

W Li, AD Kandhare, AA Mukherjee, SL Bodhankar - EXCLI journal, 2018 - ncbi.nlm.nih.gov
Background: Delayed wound healing is a diverse, multifactorial, complex and inter-related
complication of diabetes resulting in significant clinical morbidity. Hesperidin possesses …

Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin

M Kuzu, FM Kandemir, S Yıldırım, C Çağlayan… - … Science and Pollution …, 2021 - Springer
In the scope of the study, the protective effect of hesperidin (HES), a flavanone glycoside,
was investigated against sodium arsenite (NaAsO 2, SA) induced heart and brain toxicity …

Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: possible role of PPAR-γ, Bax/Bcl-2, and caspase-3

J Cui, G Wang, AD Kandhare… - Food and chemical …, 2018 - Elsevier
Background Huntington's disease (HD) is a complex multifactorial neurodegenerative
disorder. Naringin, a flavanone glycoside exhibits potent anti-inflammatory and antiapoptotic …

Naringin mitigates LPS-induced intestinal barrier injury in mice

D Luo, Z Huang, G Jia, H Zhao, G Liu, X Chen - Food & Function, 2023 - pubs.rsc.org
The aim of this study was to investigate the effect of naringin on lipopolysaccharide (LPS)-
induced jejunal barrier function in mice. Forty-five 3-week-old healthy male Balb/c mice with …

Proteomic study on the mechanism of arsenic neurotoxicity in the rat cerebral cortex and the protective mechanism of dictyophora polysaccharides against arsenic …

X Zhang, H Yang, Y Wang, J Zhang… - ACS Chemical …, 2023 - ACS Publications
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The
bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been …