The alphabet of building blocks for RNA molecules is much larger than the standard four
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …

Summary mRNA function is influenced by modifications that modulate canonical nucleobase
behavior. We show that a single modification mediates distinct impacts on mRNA translation …

In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …

Post-transcriptional RNA modifications critically regulate various biological processes. N 4-
acetylcytidine (ac4C) is an epi-transcriptome, which is highly conserved in all species …

RNA modifications play a crucial role in cancer development, profoundly influencing various
stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export …

Abstract N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification is
crucial for mRNA stability and translation efficiency, yet the underlying function in …

Abstract N4-acetylcytidine (ac4C) is a highly conserved chemical modification widely found
in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is …

In vitro maturation (IVM) refers to the process of developing immature oocytes into the
mature in vitro under the microenvironment analogous to follicle fluid. It is an important …

Chemical modifications of ribonucleotides significantly alter the physicochemical properties
and functions of RNA. Initially perceived as static and essential marks in ribosomal RNA …